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Feasibility of supercontinuum sources for use in glucose sensing by absorption spectroscopy

JUN
23
2019
23. JUN 2019

Lecture Hall ICM - Internationales Congress Center München European Conferences on Biomedical Optics (ECBO) > Preclinical and Clinical Optical Diagnostics > Novel Technologies in Optical Diagnostics I

16:45-17:00 h | ICM - Internationales Congress Center München ICM Room 2

Subjects: Biophotonics and Medical Engineering

Chairman: J. Quincy Brown (, Tulane Univ.)

Type: Lecture

Speech: English

Diabetes mellitus 1 requires tight control of the blood glucose levels to avoid harmful effects of either too high (hyperglycemia) or too low (hypoglycemia) blood sugar. Due to the availability of low-cost components, fiber-coupled near infrared (NIR) absorption spectroscopy could be a feasible measuring method. From the molar absorptivity of glucose, it is shown that to achieve high accuracy using near infrared spectroscopy for glucose sensing, relative noise levels must not exceed 0.003%. Although not common for absorption spectroscopy, supercontinuum (SC) sources are explored due to their relatively low cost and broad spectrum generation. Two SC sources (Fyla SCT500 and NKT Photonics SuperK) and one broadband lamp (Thorlabs SLS201L) were investigated with a low-cost portable spectrometer (OceanOptics NIRQuest 512-2.5). The relative intensity noise of the two SC sources could be improved by averaging, and were 0.35% (SuperK) and 0.16% (SCT500). The relative noise of the broadband source was found to be 0.40%. Due to the weak intensity, some of the broadband noise can be attributed to the detector noise. 16 aqueous glucose samples ranging from 0 to 500 mM were measured with the broadband source and the SuperK SC laser. A partial least squares regression (PLSR) model was built for both measurement sets, yielding root mean square errors of 49 and 54 mM, illustrating how the limit of detection is restrained by the high relative intensity noise. In the future, a reference arm could account for the variability of the source and enable glucose sensing using SC sources.

Informations

Silje Skeide Fuglerud

Location

Eingang
Nord-West
ICM
Eingang
Nord
Eingang
West
Atrium
Eingang
Nord-Ost
Eingang
Ost
Conference
Center Nord
Freigelände
C1
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C4
C5
C6
B0
B1
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B3
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B6
A1
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A6

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