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Lecture Hall ICM - Internationales Congress Center München European Conferences on Biomedical Optics (ECBO) > Diffuse Optical Spectroscopy and Imaging > Theory, Algorithms and Computational Tools I
10:45-11:00 h | ICM - Internationales Congress Center München ICM Room 5
Subjects: Biophotonics and Medical Engineering
Chairman: Hamid Dehghani (, The Univ. of Birmingham)
Time Domain Diffuse Optical Tomography (TD-DOT) performed at multiple wavelengths can be used to non-invasively probe tissue composition. Then, tissue composition can be related to breast tissue and lesion type. Thus, TD-DOT could be used for therapy monitoring for breast cancer. We developed a software tool for multi-wavelength TD-DOT and performed a validation on meat phantoms to mimic tissue heterogeneity. An inclusion of different meat was exploited to mimic the presence of a lesion in the breast. Results show good localization of the inclusion, but poor quantification of the reconstructed breast composition. The use of a morphological prior constraint, providing information on inclusion geometry and position, significantly improves both localization and composition estimate