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Lecture Hall ICM - Internationales Congress Center München European Conferences on Biomedical Optics (ECBO) > Diffuse Optical Spectroscopy and Imaging > Theory, Algorithms and Computational Tools II
11:15-11:30 h | ICM - Internationales Congress Center München ICM Room 5
Subjects: Biophotonics and Medical Engineering
Chairman: Eiji Okada (, Keio Univ.)
A software for fast rendering the visual appearance of a blood vessel located in human skin was developed based on a numerical solution of the radiative transfer equation. The user can specify geometrical properties, like the depth and the diameter of the vessel, and physiological properties, like the oxygen saturation of the vessel or the blood concentration in the skin. From these data the spatially and spectrally resolved reflectance from the skin containing the blood vessel is calculated via Monte Carlo simulations, by which a two dimensional image is generated. The short calculation time of about a second is achieved by precalculating and storing the spatially resolved reflectance for a variety of combinations of the optical and geometrical properties. This concept gives the user the opportunity to explore rapidly the influence of the physiological and geometrical properties of the investigated blood vessel on its visual appearance. The correctness of the lookup table was validated by comparison with independent Monte Carlo simulations. Rendering examples of different blood vessels in human skins are given. The developed framework was used to solve the inverse problem. Therefore a number of hyperspectral data sets were generated using independent Monte Carlo simulations. A Levenberg-Marquardt fit was used to determine physiological and geometrical properties from the hyperspectral data sets. Good fit results could be achieved for a number of different parameters, like the melanin concentration inside the epidermis or the radius and depth of the blood vessel.