The event database contains all event-related information for the World of Photonics Congress.
Invited Talk Hall A1 European Conferences on Biomedical Optics (ECBO) > Advances in Microscopic Imaging > Neurophotonics
10:55-11:15 h | Hall A1 Room 6 "Charles Townes"
Subjects: Biophotonics and Medical Engineering
Chairman: Emmanuel Beaurepaire (, Ecole Polytechnique)
Type: Invited Talk
Here we present label-free imaging of retinal bipolar cell axons by second-harmonic generation microscopy. The nonlinear optical signal arises from uniformly polarized microtubules, providing a surrogate contrast for the functional integrity of axons. The unique properties of microtubule SHG from the inner plexiform layer were employed for testing an outstanding hypothesis in glaucoma, namely, the persistence of BC axons in the disease during a critical period when the synaptic connections to the retinal ganglion cells are lost.