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Lecture Hall A1 European Conferences on Biomedical Optics (ECBO) > Opto-Acoustic Methods and Applications in Biophotonics > Clinical Applications II
12:15-12:30 h | Hall A1 Room 7 "Dennis Gábor"
Subjects: Biophotonics and Medical Engineering
Chairman: Daniel Razansky (, ETH Zurich)
Cancer treatments based on laser ablation (LA) are gaining popularity as an alternative to tumor resection. LA represents a minimally invasive intervention that can be selectively delivered via optical fibers or other light guides, thus leading to less pain and shorter recovery time. Monitoring of ablation procedures is essential to determine the end-point of irradiation and optimize the outcome of the interventions. Particularly, accurate measurements of the temperature and the exposure time of the treated region are crucial factors affecting the induced lesion. Imaging techniques such as computed tomography, ultrasound and magnetic resonance have been used for imaging and monitoring the ablation lesion. However, these imaging techniques have drawbacks such as requirement of contrast agents, poor spatio-temporal resolution or high cost. Optoacoustics (OA, photoacoustic) has recently been shown to provide unique properties to monitor the ablation process. Particularly, OA signals are highly sensitive to temperature variations and state-of-the-art OA systems can provide real-time imaging in entire volumes at hundreds of Hz. Herein, we demonstrate the feasibility of OA imaging with the same short-pulsed 1064 nm laser source used during the LA of murine breast tumor model. The effect of irradiation was volumetrically tracked with the OA images acquired with a 256-element spherical array. Structural damage of the tissue was clearly seen during the LA procedure.