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The event database contains all event-related information for the World of Photonics Congress.

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Increase and homogenization of the endogenous production of protoporphyrin IX by photobiomodulation

JUN
24
2019
24. JUN 2019

Lecture Hall ICM - Internationales Congress Center München European Conferences on Biomedical Optics (ECBO) > Translation of Lasers and Biophotonics Technologies and Procedures: Toward the Clinic > PDT Delivery and Monitoring II

12:30-12:45 h | ICM - Internationales Congress Center München ICM Room 11

Subjects: Biophotonics and Medical Engineering

Chairman: Mikhail Kirillin (, Institute of Applied Physics)

Type: Lecture

Speech: English

Photodynamic therapy (PDT) and/or photodetection (PDD) based on protoporphyrin IX (PpIX) are used in many medical fields. However, the endogenous production of PpIX in the tissue after administration of its precursor, 5-aminolevulinic acid (ALA), is frequently insufficient and, in particular, inhomogeneous, leading to unsatisfactory treatment outcomes or false negatives. Photobiomodulation (PBM), which is based on the application of a sub-thermal dose of red or near infra-red light (typically in the range of 600 – 900 nm), is known to modulate, among others, the cell metabolism, as demonstrated by an increased production of adenosine triphosphate and changes of the mitochondrial potential. Yet, the precise mechanism of PBM and, furthermore, the optimal irradiation conditions are to be determined. In the work reported here, we have studied the dependence of the endogenous PpIX production by U-87 glioma cells on various PBM irradiation protocols (wavelengths, irradiations, light doses). We have shown that PBM can increase, and even homogenize the endogenous production of PpIX in these cells. Therefore, combining PBM with PDT or PDD could lead to more potent and satisfying cancer treatments or detections outcomes, in particular in neurosurgery, dermatology, and urology.

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Location

Eingang
Nord-West
ICM
Eingang
Nord
Eingang
West
Atrium
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Nord-Ost
Eingang
Ost
Conference
Center Nord
Freigelände
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C6
B0
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